The Sun is a major focus of space exploration. Being above the atmosphere in particular and Earth's magnetic field gives access to the solar wind and infrared and ultraviolet radiations that cannot reach Earth's surface. The Sun generates most space weather, which can affect power generation and transmission systems on Earth and interfere with, and even damage, satellites and space probes. Numerous spacecraft dedicated to observing the Sun, beginning with the Apollo Telescope Mount, have been launched and still others have had solar observation as a secondary objective. Parker Solar Probe, launched in 2018, will approach the Sun to within 1/8th the orbit of Mercury

The Venus is the first target of interplanetary flyby and lander missions and, despite one of the most hostile surface environments in the Solar System, has had more landers sent to it (nearly all from the Soviet Union) than any other planet in the Solar System. The first flyby was the 1961 Venera 1, though the 1962 Mariner 2 was the first flyby to successfully return data. Mariner 2 has been followed by several other flybys by multiple space agencies often as part of missions using a Venus flyby to provide a gravitational assist en route to other celestial bodies. In 1967 Venera 4 became the first probe to enter and directly examine the atmosphere of Venus. In 1970, Venera 7 became the first successful lander to reach the surface of Venus and by 1985 it had been followed by eight additional successful Soviet Venus landers which provided images and other direct surface data. Starting in 1975 with the Soviet orbiter Venera 9 some ten successful orbiter missions have been sent to Venus, including later missions which were able to map the surface of Venus using radar to pierce the obscuring atmosphere.

The Moon was the first celestial body to be the object of space exploration. It holds the distinctions of being the first remote celestial object to be flown by, orbited, and landed upon by spacecraft, and the only remote celestial object ever to be visited by humans. In 1959 the Soviets obtained the first images of the far side of the Moon, never previously visible to humans. The U.S. exploration of the Moon began with the Ranger 4 impactor in 1962. Starting in 1966 the Soviets successfully deployed a number of landers to the Moon which were able to obtain data directly from the Moon's surface; just four months later, Surveyor 1 marked the debut of a successful series of U.S.

Crewed exploration of the Moon began in 1968 with the Apollo 8 mission that successfully orbited the Moon, the first time any extraterrestrial object was orbited by humans. In 1969, the Apollo 11 mission marked the first time humans set foot upon another world. Crewed exploration of the Moon did not continue for long. The Apollo 17 mission in 1972 marked the sixth landing and the most recent human visit. Artemis 2 will flyby the Moon in 2022. Robotic missions are still pursued vigorously.

The exploration of Mars has been an important part of the space exploration programs of the Soviet Union (later Russia), the United States, Europe, Japan and India. Dozens of robotic spacecraft, including orbiters, landers, and rovers, have been launched toward Mars since the 1960s. These missions were aimed at gathering data about current conditions and answering questions about the history of Mars. The questions raised by the scientific community are expected to not only give a better appreciation of the red planet but also yield further insight into the past, and possible future, of Earth.Mars is the prime candidate where humans could live outside the Earth and the technology to reach Mars is possible.

The exploration of Mars has come at a considerable financial cost with roughly two-thirds of all spacecraft destined for Mars failing before completing their missions, with some failing before they even began. Such a high failure rate can be attributed to the complexity and large number of variables involved in an interplanetary journey

In contrast to overall high failure rates in the exploration of Mars, India has become the first country to achieve success of its maiden attempt. India's Mars Orbiter Mission (MOM) is one of the least expensive interplanetary missions ever undertaken with an approximate total cost of ₹ 450 Crore (US$73 million).